摘要
目的:观察储铁水平和动脉粥样硬化(AS)危险因素的关系,探讨铁参与AS发生和发展的可能机制.方法:选取59例AS患者和60例体检健康者,测定机体储存铁水平方面的指标,如血清铁蛋白、血清铁,测定与AS有关的一些指标,如C-反应蛋白、超氧化物歧化酶、总抗氧化能力等.结果:AS组的血清铁蛋白水平明显高于对照组,为(217.02±136.65)ng/ml对(117.75±47.89)ng/ml.血清铁蛋白水平与舒张压及收缩压呈正相关(γ=0.357,0.344).AS组的C-反应蛋白水平明显高于对照组.结论:AS患者体内有较高的铁储存,血清铁蛋白水平可作为AS的一个监测指标.
Objective： To evaluate the relationship between body iron status and atherosclerosis（AS） risk factors , so as to explain the possible mechanism for iron initiating and promoting atherosclerosis. Methods： The study population comprises 59 patients with AS and 60 healthy controls. Stored iron （such as serum ferritin, serum iron） and risk factors of AS （C-reactive protein, superoxide dismutase, total antioxidative capacity） were measured. Results.. The serum concentration of serum ferritin was significantly higher in patients than that in controls[（217.02± 136.65 ng/ml vs. （117.75±47.89）ng/ml）], There were positive correlation between serum ferritin and DBP（r=0. 357） ,SBP（r=0. 344）, The AS group shown higher CRP relatively to the control group. Conclusions：The present study found that there is significantly higher level of serum ferritin in atherogenesis. Level of serum ferritin can be regarded as a monitor for the development of AS.
