活血解郁汤治疗开颅术后抑郁症45例疗效观察

Clinical Observation on Effect of Huoxue Jieyu Decoction in Treating Depression after Craniotomy: A Report of 45 Cases

目的观察活血解郁汤治疗开颅术后抑郁症患者的临床疗效。方法将90例患者以就诊先后顺序随机分为两组,治疗组(45例)在常规对症治疗的基础上口服自拟活血解郁汤,对照组(38例)在常规对症治疗的基础上口服安拿芬尼,并对两组患者治疗前后进行汉密尔顿抑郁量表(HAMD)评分,观察近远期疗效和药物不良反应等。结果两组近期疗效相当,远期疗效中治愈率治疗组优于对照组(P<0.05),两组治疗前后HAMD评分比较差异无显著性,但药物不良反应发生率治疗组低于对照组(P<0.01)。结论活血解郁汤治疗开颅术后抑郁症疗效与安拿芬尼基本一致,不良反应明显少于安拿芬尼,且远期疗效稳定。

Objective To observe the therapeutic effect of Huoxue Jieyu decoction （HJD） on patients with depression after craniotomy. Methods Ninety patients were randomly divided into 2 groups according to the sequence of their consultation. The 45 patients in the treated group were treated with conventional symptomatic treatment plus oral administration of HJD, and the 38 patients in the control group were treated in the same way but with chlorimipramine （anafranil） instead of HJD. Hamilton depression （HAMD） scores before and after treatment, occurrence of adverse effects and long-term therapeutic effect of treatment were observed. Results The score of HAMD was insignificantly different in 2 groups before and after treatment （P〉0.05）, but the occurrence of adverse effects between them was significantly different （P （0.01）. Conclusion The therapeutic effect of HJD on depression was similar to that of anafranil, but HJD has less adverse effect and more stabilized long-term effect.