血糖与血清C反应蛋白关系的研究

Relationship between blood glucose and C-reactive protein.

目的观察2型糖尿病T2DM和糖耐量低减IGT患者血清C反应蛋白CRP的水平,探讨CRP在高血糖发生中的作用。方法所有受试者均经口服葡萄糖耐量试验OGTT,用乳胶增强速率免疫散射比浊法测定三组受试者血清CRP水平。结果正常对照NCI、GT和T2DM者血清CRP水平逐渐升高,分别为(1.31±0.47)mg/L、(2.43±0.40)mg/L和(3.95±0.88)mg/L,组间比较差异有统计学意义,以下同(P<0.01);CRP分别与体重指数BMI、腰围、收缩压、舒张压、空腹血糖FPG、OGTT2 h PG、HbA1c、胰岛素抵抗指数HOMA-IR、三酰甘油三酯TG和总胆固醇TC呈正相关。结论慢性低度炎症不仅在T2DM而且在IGT状态已经存在。

Objective To observe the levels of C - reactive protein（CRP） in patients with type 2 diabetes mellitus（T2DM）and impaired glucose tolerance（IGT）, and to study the rule of CRP in the development of hyperglycemia. Methods All subjects in the study underwent a 75 g oral glucose tolerance test （OGTY）. Determination of serum CRP levels in normal controls（NC）, IGT and T2DM patients was made by latex - enhanced immunonephelometric assay. Results The serum levels of CRP were 1.31 ± 0.47mg/L in NC,2.43 ± 0.40 mg/L in IGT patients, and 3.95 ± 0.88 mg/L in T2DM patients. The serum levels of CRP were positively correlated with body mass index（BMI）（ r = 0.275, P 〈0.05）, waist circumference（ r =0.354, P 〈0.01）, systolic blood pressure（ r = 0.247, P 〈0.05）, diastolic blood pressure r =0.233, P 〈0.05）, fasting plasma glucose（FPG r=0.513, P〈0.01）, OGTY2 h PG（ r=0.526, P 〈0.01）, hemoglobin Alc HbAlc r = 0.483, P 〈 0.01）, homeostasis model assessment index of insulin resistance（HOMA- IR r=0.503, P 〈 0.01）, triglyceride r =0.381, P 〈0.01） ,and total cholesterol（TC） （ r = 0.282, P 〈 0.05）. Conclusion Low- grade chronic inflammation exists not only in patients with T2DM but also in patients with IGT.