宫颈小细胞癌组织中血管内皮生长因子的表达及临床意义

Expression of vascular endothelial growth factor in small cell carcinoma of uterus cervix and its clinical significance

目的:检测血管内皮生长因子(VEGF)在宫颈小细胞癌(SCCC)中的表达及其与SCCC病理和临床的关系,为预测SCCC转移、评价预后及合理治疗提供科学依据。方法:采用免疫组化EnV ision二步法检测VEGF在SCCC中的表达。结果:4例SCCC组织中VEGF均为阳性。结论:VEGF与SCCC的发生、发展密切相关,SCCC早期即有淋巴结转移、脉管浸润以及病情进展迅速均与VEGF的高表达有关。VEGF可作为评估SCCC的淋巴结转移状况、选择治疗方案及判断预后的指标。

Objective： To study the expression of vascular endothelial growth factor（VEGF） in small cell carcinoma of cervis （ SCCC ） and its relationship with the clinical and pathological features, so as to predict the metastasis of SCCC, to evaluate the prognosis and to manage a proper treatment. Methods ： EnVision two step immunohistochemical method was used to observe the expession of VEGF in the samples of small cell carcinoma of cervis. Results ： Four samples were obtained from surgical specimens of the patients with SCCC in our hospital. In all the samples, the expression of VEGF was positive. Conclusion： VEGF is closely related with the oncogenesis and development of SCCC. In the earlier period of SCCC, the lymph node involvement and vascular invasion are common. The aggressive progression of SCCC must have something to do with the highly expression of VEGF. The expression of VEGF can be used as an index in selecting treatment and predicting prognosis of SCCC.