成纤维细胞生长因子与中枢神经系统发育及生理

Development and physiology of central nervous system with fibroblast grow factors

成纤维细胞生长因子(FGF)对中枢神经系统发育及成体生理功能调节至关重要。在胚胎发育初期,FGF可诱导原肠胚形成期间的细胞迁移和神经板前后体轴的建立;在较迟的大脑塑型过程中,控制大脑组织分化和结构特化;在成年期大脑及神经组织损伤时,保持成体干细胞增生活性并支持中枢神经再生和修复。

Fibroblast grow factors are important regulators of the embryonic and adult central nervous system during developmental processes and adult physiology. FGF control cell migration and establishment of the anterior-posterior body axis of the neural plate during gastrulation. At later shaping stage of the brain, FGF function in those organs and tissues control the morphogenesis and differentiation. During adult and injured in the adult brain, FGF contain the active hyperplasia of the adult stem ceils and promote regeneration and repair in the central nervous system. This article mainly reviews the function of FGF family members in the central nervous system.