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成纤维细胞生长因子与中枢神经系统发育及生理 被引量:2

Development and physiology of central nervous system with fibroblast grow factors
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摘要 成纤维细胞生长因子(FGF)对中枢神经系统发育及成体生理功能调节至关重要。在胚胎发育初期,FGF可诱导原肠胚形成期间的细胞迁移和神经板前后体轴的建立;在较迟的大脑塑型过程中,控制大脑组织分化和结构特化;在成年期大脑及神经组织损伤时,保持成体干细胞增生活性并支持中枢神经再生和修复。 Fibroblast grow factors are important regulators of the embryonic and adult central nervous system during developmental processes and adult physiology. FGF control cell migration and establishment of the anterior-posterior body axis of the neural plate during gastrulation. At later shaping stage of the brain, FGF function in those organs and tissues control the morphogenesis and differentiation. During adult and injured in the adult brain, FGF contain the active hyperplasia of the adult stem ceils and promote regeneration and repair in the central nervous system. This article mainly reviews the function of FGF family members in the central nervous system.
出处 《医学研究生学报》 CAS 2005年第11期1041-1044,1048,共5页 Journal of Medical Postgraduates
基金 国家自然科学基金资助项目(批准号:30470604) 中国博士后科研基金资助项目(批准号:2003034384) 江苏省自然科学基金资助项目(批准号:BK2004425)
关键词 成纤维细胞生长因子 中枢神经系统 发育 干细胞 Fibroblast grow factor Central nervous system, development Stem cell
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  • 1Dono R, Faulhaber J, Galli A,et al. FGF2 signaling is required for the development of neuronal circuits regulating blood pressure[J]. Circ Res,2002, 90(1): E5-E10.
  • 2Schoorlemmer J, Goldfarb M. Fibroblast growth factor homologous factors are intracellular signaling proteins [J]. Curr Biol,2001,11 (10) :793-797.
  • 3Wilson SI, Edlund T. Neural induction: toward a unifying mechanism[J]. Nat Neurosci Suppl,2001, 4(11):1161-1168.
  • 4Sasai Y, Lu B, Piccolo S,et al. Endoderm induction by the organizer-secreted factors chordin and noggin in Xenopus animal caps[J]. EMBO J,1996, 15(17): 4547-4555.
  • 5Streit A, Berliner A J, Papanayotou C,et al. Initiation of neural induction by FGF signalling before gastrulation [J]. Nature,2000,406(6791):74-78.
  • 6Ragsdale CW, Grove EA. Patterning the mammalian cerebral corte[J]. Curr Opin Neurobiol,2001,11 (1):50-58.
  • 7Raballo R, Rhee J, Lyn-Cook R,et al. Basic fibroblast growth factor (Fgf2) is necessary for cell proliferation and neurogenesis in the developing cerebral cortex[J]. J Neurosci,2000,20(13):5012-5023.
  • 8Pappas IS, Parnavelas JG. Basic fibroblast growth factor promotes the generation and differentiation of calretinin neurons in the rat cerebral cortex in vitro [J]. Eur J Neurosci, 1998,10 (4): 1436-1445.
  • 9Qian X, Davis AA, Goderie SK,et al. FGF2 concentration regulates the generation of neurons and glia from multipotent cortical stem cells [J]. Neuron, 1997,18 (1):81-93.
  • 10Vaccarino FM, Schwartz ML, Raballo R,et al. Changes in cerebral cortex size are governed by fibroblast growth factor during embryogenesis[ J]. Nat Neurosci, 1999,2 (3) :246-253.

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