非小细胞肺癌血清血管内皮生长因子水平的变化及其意义

Change an significance of vascular endothelial growth factor level in serum of patients with non-small cell lung cancer

目的探讨非小细胞肺癌(NSCLC)患者术前血清血管内皮细胞生长因子(VEGF)的水平及其诊断价值。方法采用酶联免疫吸附法(ELISA)检测32例NSCLC患者、19例肺部良性疾病患者和30例健康人血清中VEGF水平。结果NSCLC患者血清VEGF水平[(16.27±2.32)μg/L]明显高于肺良性疾病患者[(11.08±2.20)μg/L]和健康人[(10.52±2.03)μg/L](P<0.01);VEGF水平与P-TNM分期、淋巴结转移情况、肿瘤细胞分化程度密切相关(P<0.01);血清VEGF≥14.58mg/L诊断NSCLS的灵敏度和特异性分别是71.88%和93.33%。结论血清VEGF可作为判断NSCLC侵袭和转移状态的生物学指标。

Objective To determine the serum vascular endothelial growth factor （VEGF） level in patients with non-small cell lung cance（NSCLC） and explore its diagnostic value. Methods 32 NSCLS patients, 19 patients with lung benign tumor and 30 healthy control subjects were included in this study. Serum VEGF level was measured by sandwith ELISA. Results Serum VEGF level in NSCLC （ 16.27 ± 2.32 μg/ml ） was significantly higher than those of lung benign tumor （ 11.08 ± 2.02 μg/ml ） and those of healthy subjects （10.52 ± 2.03 μg/ml）（ P 〈 0. 001）o The serum VEGF level in NSCI.C was closely related to P-T.NM stages, lymph nede metastasis status and cell differentiation grade （P 〈 0.001）. Using the criterion of serum VEGF level≥14.58 μg/ml, the sensitivity and specificity of the diagucsis for NSCLC were 71.88 % and 93.33 %, respectively. Conclusion The level of serum VEGF could be corsidered as a useful biological indicator to evaluate invasion and metastasis of NSCLC.