汕头市孕妇生殖器疱疹血清流行病学初步调查研究

Preliminary study on serum epidemiological prevalence of HSV-II infection among pregnant women in Shantou

目的:调查汕头市不同年龄段、不同孕期、不同妊娠史和不同职业孕妇血清中HSV-2特异性抗体IgG的存在情况.方法:随机选取汕头市520例无症状的正常孕妇进行研究,采用酶联免疫吸附法(ELISA)检测孕妇血清中HSV-2特异性抗体IgG.结果:共调查520例孕妇,阳性率为26.2%(136/520),不同孕期感染率无显著性差异;年龄在26～35岁孕妇、有异常妊娠史、文化程度低的孕妇HSV感染的危险性高.结论:孕妇HSV-2感染率高,对孕妇进行HSV-2感染的血清学监测,有利于识别有生殖器疱疹危险因素的孕妇和亚临床型孕妇,降低漏诊率,对预防新生儿HSV感染、降低流产、早产和死产的发生具有十分重要的意义.

Objective： To determine the serum epidemiological prevalence of herpes simplex virus type. 2 （HSV - 2） IgG antibody in pregnant women in Shantou. Methods： Enzyme- linked immunosorbent assay （ELISA） was applied to detecte HSV - 2 in sera of 520 pregnant women. Results： The prevalence of HSV - 2 infection was 26.2% （136/520）. There was no difference of the infection between different age and gestation stage. The infection rates were higher in the women aged 26 to 35 years, with abnormal pregnancy and with lower education. Conclusion： The prevalence of HSV - 2 infection in pregnant women is high in the study population. Women with asymptomatic or subcIinical genital HSV - 2 infection should be screened for HSV - 2 IgG antibody to reduce the abnormal pregnancy outcome.