来氟米特对家兔动脉粥样硬化形成的影响

Effects of Leflunomide on Experimental Atherogensis of Rabbits

目的研究免疫抑制剂来氟米特对兔动脉粥样硬化形成的影响。方法24只新西兰大白兔随机分为三组:正常饮食组、高脂饮食组和高脂饮食+来氟米特治疗组。在0周和8周时测定血清中血脂、肿瘤坏死因子α、白介素介素6浓度。免疫组织化学染色测定斑块处巨噬细胞数量。图像分析观察主动脉斑块内膜面积比。结果来氟米特对血脂无明显影响,但可使肿瘤坏死因子α、白介素介素6、主动脉斑块内膜面积比及斑块处的巨噬细胞数较高脂饮食组显著降低(P均<0.001)。结论来氟米特可显著抑制动脉粥样硬化部位的炎症反应,对兔动脉粥样硬化有预防作用。

Aim To access the effects of leflunomide on experimental atherogensis of rabbits. Methods 24 New Zealand White rabbits were devided into three groups, 8 rabbits were selected as normal-diet control group, 8 rabbits as high-dlet control, the others as treatment group administered with leflunomide （5 mg/d）..Serum lipids, intedeuldn-6 （IL-6）, tumor necrosis factor-alpha （TNF-α）, atherosclerotic plaque/intima size ratio of aorta and the number of infiltrating macrophage in plaques were detected on the 0, 8 th week. Results Leflunomide had no effect on the lipids compared with control groups, the level of circulating TNF-α, IL-6, plaque/intima size ratio and the number of infiltrating macrophage in the treatment group was lower than that of control groups （all P 〈 0.001 ）. Conclusions LEF oould inhibit the inflammation in the lesion of atheroselerosis of rabbits and attenuate atherogensis of rabbits.