2型糖尿病患者血浆血管性假血友病因子与血清C反应蛋白的相关性

The Associative Relationship of Plasma von Willebrand Factor and Serum C-Reactive Protein in New Diagnostic Type 2 Diabetic Patients

目的了解2型糖尿病患者血管内皮细胞功能损害指标血管性假血友病因子水平与血清炎性反应指标C反应蛋白的相关关系。方法入选新诊断空腹血糖大于10mmolL的2型糖尿病患者93例,空腹取静脉血留取血浆及血清,酶联免疫吸附法测定血浆血管性假血友病因子及血清C反应蛋白浓度,并进行相关性分析。结果2型糖尿病患者血浆血管性假血友病因子及血清C反应蛋白均显著高于正常对照组,相关分析发现2型糖尿病患者血浆血管性假血友病因子与血清C反应蛋白浓度无相关关系。结论2型糖尿病患者存在血管内皮细胞功能损害及慢性炎症反应,血管性假血友病因子与C反应蛋白是两个不相关联的致糖尿病患者动脉粥样硬化因素。

Aim To investigate the association of the blood yon Willebrand factor （vWF） and C-reactive protein （CRP） of diabetes. Methods Blood specimens of 93 new diagnotic diabetic patients whose blood glucose level was more than 10 mmol/L were collected. The vWF and CRP were assayed by ELISA. Results The level of vWF and CRP of diabete group increased significantly than the control normal group, there were not any associative relationship in the level of Mood vWF and CRP. Conclusions The elevated concentration of plasma vWF anti serum CRP showed that the new diagnotic diabetic patients had the endothelia ceLl dysfunction anti chronic systemic irflammation, vWF anti CRP were the independent promoting factor of atherosclerosis.