重组IL－2及T细胞亚群对全身型重症肌力周围血B细胞功能的影响

THE EFFECTS OF RECOMBINANT INTERLEUKIN 2 AND T-CELL SUBSETS ON PERIPHERAL B CELL IN MYASTHENIA GRAVIS PATIENT

对１２例全大型重症肌无力（ＭＧ）患者周围血Ｂ细胞增殖及分化能力进行了研究，并观察重组白细胞介素２（ｒＩＬ－２）及Ｔ细胞亚群对其直接与间接影响。结果表明：①ＭＧ患者周围血Ｂ细胞的增殖能力高于健康人，ｒＩＬ－２及Ｔ细胞亚群可促进Ｂ细胞的增殖；②去ＣＤ８＋细胞后ＡＣｈＲ－ａｂ的产生无明显增加；③去ＣＤ４＋细胞组加入ｒＩＬ－２后ＡＣｈＲ－ａｂ产生减少。提示ｒＩＬ－２对ＭＧ患者有潜在的治疗价值。

he proliferation and differentiation of B lymhocytes from the peripheral blood were studiedin 12 myasthenia gravis(MG)patients and 10 healthy volunteers. The purpose of this researchwas to investigate the effects of recombinant interleukin 2(rIL-2)and T lymphocytes subsets bydirect or indirect way on proliferation and differentiation of B cells from the peripheral blood inMG patients. The results showed that(1)the capacity of peripheral B cells proliferation in MGgroup was stronger than that in healthy group and it is enhanced by rlL-2 and T cell subsets.(2)there was no significant increase in AChR-ab production by removing CD8+ T cells comparedwith the unfractionated T cell groups. (3)the production o AChR-ab was decreased when rIL-2was added in the presence of CD8+ T cell groups. It is suggested that rlL-2 might have potentialvalue for treatment of MG.