慢性肺源性心脏病外周血TNF和Fn水平及其意义

THE LEVELS OF PERIPHERAL BLOOD TUMOR NECROSIS FACTOR ANDFIBRONECTIN IN PATIENTS WITH CHRONIC PULMONARY HEART DIAEASE

应用ＥＬＩＳＡ的免疫火箭电泳法检测慢性肺源性心脏病（ＣＰＨＤ）急性加重期患者及正常人对照血清的肿瘤坏死因子（ＴＮＦ）和血浆纤维连接蛋白（Ｆｎ）。结果显示，ＣＰＨＤ患者ＴＮＦ较对照组明显增高（Ｐ＜０．０１），而Ｆｎ则明显降低（Ｐ＜０．０１），尤见于３例死亡病例的生前情况。提示（ＣＰＨＤ）患者外周血ＴＮＦ升高和Ｆｎ下降可能是ＣＰＨＤ发病机制中微循环障碍的重要环节。观察血浆ＴＮＦ和Ｆｎ水平有助于估计ＣＰＨＤ的病情和预后。

he levels of tumor necrosis factor(TNF)and fibronecth(Fn)in peripheral blood weredetermined by means of the enzyme linked immunosorbent assays(ELISA)and the rocket elec-trophoresis in 30 patients with chronic pulmonary heart disease(CPHD group),and 30 riormalhealthy persons(control group).The result showed that serum level of TNF in CPHD group waselevated significantly on admission as compared with tliat of the control group(P<0.01).Plas-ma Fn level in CPHD was significantly decreased on admission as compared with that in the nor-mal control group(P<0.01). The data suggest that increased TNF and decreased Fn mfly play an important role in distur-bance of pulmonary micro-circulation in the course of CPHD,It is indicated that CPHD,for im-proving pulmonary microcirculation and decreasing pulmonary hypertension in patients withCPHD at the early stage.