慢性肺心病血清酶活性与缺氧程度及预后的关系

Relationship of Serum Enzyme Activity and Degree of Hypoxia and its Prognosis of CPHD

目的探讨慢性肺原性心脏病(肺心病)患者与血清酶学活性、缺氧程度及预后的关系。方法对78例肺心病患者分为临床缓解期(病情缓解后1周)和急性发作期两组,急性发作期者分为轻、中、重度缺氧3组,以健康成年人为对照组,检测血清中6种酶(肌酸激酶CPK、乳酸脱氢酶LDH、天冬氨酸氨基转移酶AST、α-羟丁酸脱氢酶HBD、丙氨酸氨基转移酶ALT、γ-谷氨酰转肽酶γ-GT)的活性及动脉血氧分压(PaO2)、血氧饱和度(SaO2),并进行分析。结果发现肺心病各期(临床缓解期和急性发作期)患者CPK酶活性的变化与正常对照组无统计学差异(P>0.05),其他5种血清酶活性均有不同程度的升高;肺心病急性发作期轻、中、重度缺氧3组患者间经方差分析,除CPK外,LDH、AST、HBD、ALT、γ-GT活性均明显升高,且随着缺氧越严重,该5种酶活性则升高越明显,具有显著性统计学差异(P<0.01)。结论肺心病患者血清酶(LDH、AST、HBD、ALT、γ-GT)活性的变化可反映病情发展的程度,其血清酶活性与缺氧严重性密切相关,缺氧越严重,酶活力增高越明显。血清酶活力显著增高是病情危重信号,是判断预后的可靠指标。

Objective To discuss the rehfionship of serum enzyme activity and degree of hypoxia and its prognosis of CPHD. Methods 78 of such patient were divided into clinical paracmasia and acute episode stage. In the acute episode stage were also divided into slightly, moderate and severe groups. The healthy adults were as control. The enzymes were detected such as CDK, LDH, AST, HBD,ALT and so on also the SaO2. The results were analyzed. Results The CPK activity had no significantly changed in varied groups. The other 5 kinds of enzymes were increased with the degree of hypoxia with significant difference. Conclusion The LDH.AST.HBD.ALT. γ - GT might reflect the situation of the patient and its getting higher might related with the severe of hypoxia which are the assessment data of the prognosis.