摘要
对41例单纯性肾病综合征(简称肾病)患儿,给予泼尼松中长程疗法治疗。其中20例(A组)同时反复接受静脉输入白蛋白治疗,剂量为4.9±2.1克/次;余21例(B组)为对照组。结果表明,A组患儿于治疗期间出现BUN增高,平均水肿消退时间、肾病达缓解时间均较B组显著延迟,分别延迟至21.4±2.6(x±sx)天(B组为6.9±0.5天)、34.8±3.7(x±sx)天(B组为11.4±1.5天);复发率显著高于B组。提示反复输入白蛋白不利于单纯性肾病缓解,并可增加复发。
Forty-onechildrenwithidiopathicnephroticsyndrome(INS)treatedwithmiddletolong-termsteroidsweredividedintotwogroups.TwentycasesingroupAreceivedalbuminbyintra-venousinfusion(4.9±2.1geachtime,for3~12times).Twenty-onecasesingroupBwereascon-trols.Thedatashowedthat(1)ingroupA,thevalueofserumBUNwereincreasedsignificantlywiththeuseofalbumin;(2)ittook24.4±2.6(x±sx)daystoremoveedemaingroupA,VS.6.9±0.5(x±sx)daysincontrols(P<0.01);(3)ittook34.8±3.7(x±sx)daystoeliminateprotein-uriaingroupA,VS.11.4±1.5(x±sx)daysincontrols(P<0.01);(4)therecurenecerate(88.9%)ofINSingroupAwassignificantlyhigherthanthat(38.1%)ingroupB.Itisindicatedthatrepeatedlyintravenousalbumininfusionmaybeoneofthecausativefactors,withwhichINSrelapseandbecomerefractory.
出处
《中华儿科杂志》
CAS
CSCD
北大核心
1996年第2期98-100,共3页
Chinese Journal of Pediatrics