慢性根尖周病的病理及免疫特性研究

The study on Pathologic and Immunologic Character of Chronic Periapical Lesions

本文对７例根尖肉芽肿及５例根尖囊肿进行了病理及免疫组化研究。结果显示该二种病变均以炎性肉芽组织为其主要组织结构。浸润之慢炎细胞都以淋巴细胞为主，另有一定量浆细胞及巨噬细胞。免疫组化染色显示浸润的淋巴细胞包括Ｔ、Ｂ两类，以Ｔ细胞占明显优势。该结果提示慢性根尖周病发展过程中，体液免疫及细胞免疫同时参与作用，但细胞免疫占主导地位。根尖肉芽肿及根尖囊肿在病理改变上及免疫特性上的一致性也为根尖肉芽肿可能向根尖囊肿转化提供了理论依据。

Twelve cases of periapical lesions were studied by light microscopy and immunohistochemical stain.The results in dicated that periapical granuloma and periapical cysts mainly consisted of granulation tissue.The majority of inflammatary cells were lymphocytes.T cells were more numerous than B cells.It suggests that humoral and cellular immunological reactions participate in pathogenesis of these lesions.And cellular immunological reaction has a decisive function.The similar features in Pathology and immunology between the two lesions showed us a basic condition for periapical granuloma changing to periapical cyst.