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盖诺联合吡柔比星治疗转移性乳腺癌临床观察

NVB combined with THP for treatment of metastatic breast cancer
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摘要 目的观察盖诺(NVB)联合吡柔比星(THP)治疗转移性乳腺癌的疗效和毒性。方法NVB 25 mg/m2,静脉冲入,第1、8天;THP 40 mg/m2,静脉冲入,第2天,21 d为1个周期。结果完全缓解5例,部分缓解19例,总有效率60.0%。主要毒性为较重的骨髓抑制,其中Ⅲ、Ⅳ度白细胞减少占57.5%。结论NVB+THP联合治疗转移性乳腺癌疗效较好,且对以往用过阿霉素复发转移患者也有一定疗效。心脏毒性轻,不良反应可以防治。 Objective To evaluate the efficacy and toxicity of NVB and THP combined chemotherapy (NT regimen) in treatment of metastatic breast cancer.Method NVB was given at a dose of 25 mg/m^2 on days 1 and 8, THP 40 mg/m^2 on day 2 intravenously every 3 weeks.Results There were 5 complete response and 19 partial response. The overall response rate was 60.0%. Main common toxic reactions were serious myelosuppression and grade-Ⅲ and-Ⅳ leukopenia seen in 57.5% of patients. Conclusion The NT combined chemotherapy is effective for metastatic breast cancer and also effective in patients who had been treated with doxorubicin. Its cardiotoxicity is light and its adverse reaction can be prevented.
作者 何聪玲
出处 《中国肿瘤临床与康复》 2005年第5期421-422,共2页 Chinese Journal of Clinical Oncology and Rehabilitation
关键词 乳腺肿瘤/化学疗法 盖诺 吡柔比星 Breast neoplasms/chemotherapy NVB THP
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