摘要
目的观察长春瑞滨治疗多发性骨髓瘤的临床疗效和毒副作用。方法治疗组在VAD方案中,用长春瑞滨(NVB)代替长春新碱(VCR)与吡喃阿霉素、地塞米松组成NTD方案治疗多发性骨髓瘤10例;对照组以长春地辛(VDS)代替长春新碱与吡喃阿霉素、地塞米松组成VTD方案治疗多发性骨髓瘤10例,比较两组的疗效和毒副作用。结果两组总有效率均为70.0%;VTD组周围神经毒性发生率为40.0%,NTD组为10.0%。结论NTD方案对多发性骨髓瘤有较好的治疗效果,周围神经毒性有明显降低的趋势。
Objective To investigate the clinical efficacy and toxicity of navelbine（NVB） in treatment of multiple myeloma. Methods Ten patients with multiple myeloma were treated by NTD regimen（NVB, pimrubicin, dexamethasone）. In the control group, 10 patients were treated by VTD regimen（vindesine, pirambicin and dexamethasone） .Results The overall response rate of two group were all 70.0% .qhe rate of neurologic toxicity in VTD group and NTD group were 40.0% and 10.0% respeetively.Conclusion There was fairly efficacy of NTD regimen in patients with multiple myeloma. Compared with VTD regimen, the rote of neurologic toxicity tended to decrease in NTD regimen.
出处
《中国肿瘤临床与康复》
2005年第5期431-433,共3页
Chinese Journal of Clinical Oncology and Rehabilitation
