中药复方对实验性老年高脂血症红细胞免疫粘附功能和循环免疫复合物的作用

STUDYON CHINESE HERBS INFLUENCE ON FUNCTION OF ERYTHROCYTE IMMUNE ADHERENCE AND THE CONTENT OF CIRCULATORY IMMUNE COMPLEX OF EXPERIMENTAL SENILEHYPERLIPEMIA

用高脂饲料喂饲老龄豚鼠，造成“实验性老年高脂血症”的模型，观察补肾化痰祛瘀中药复方对实验动物的红细胞免疫粘附功能和循环免疫复合物（ＣＩＣ）含量的作用。结果显示，随着高脂血症的形成，实验动物的红细胞Ｃ＿（３ｂ）受体（ＲＢＣ－Ｃ＿（３ｂ）Ｒ）花环率下降，红细胞免疫复合物（ＲＢＣ－ＩＣ）花环率和ＣＩＣ含量上升，造模前、后差异显著（Ｐ分别小于０．０１，０．００５）。ＣＩＣ含量与ＲＢＣ－Ｃ＿（３ｂ）花环率、ＲＢＣ－ＩＣ花环率呈负、正相关（Ｐ均小于０．０５）。该复方在不限制高脂饮食的条件下，能提高红细胞免疫粘附功能和降低ＣＩＣ含量，具有预防和治疗双重作用。

It has been observed that how the prescription of tonifying kidney to remove phlegm and blood stasis influence on function of erythrocyte immune adherence and content circulatory immune complex(CIC)of experimental senile hyperlipemia. The results showed there is a decline in garland rate of red blood cell C3b receptors(RBC-C3bR),but increase in garland rate of red blood cell immune complex(RBC-IC)and content of CIC when hyperlipemia of experiment animal form. There is a significant different before and after animal test model made( P<0.01,0. 005).There are negative and positive correlation between the content of CIC and garland rate of RBC-C3bR, and RBC-IC(both P <0. 05). The prescription has double functions in treatment and prevention of senile hyperlipemia by increasing function of erythrocyte immune adherence and decreasing the content of CIC without limitation of high fat diet.