阿魏酸钠对小鼠谷胱甘肽及相关酶活性的影响

Effects of Sodium Ferulate on Liver Glutathione and Glutathione-related Enzymes in Mice

阿魏酸钠(SF)能降低对乙酰氨基酚(Par)对肝损害小鼠的血清丙氨酸转氨酶(ALT)活性和肝细胞浆谷胱甘肽过氧化物酶(GSH-Px)活性,增加肝微粒体、胞浆谷胱甘肽 S-转移酶(GST)活性及线粒体 GSH 含量,同时使正常小鼠肝微粒体 GST 活性及蛋白含量亦有增加。表明 SF 能增加肝脏的解毒能力。

Effects of sodium ferulate on liver glutathione (GSH) and GSH related enzymes have been investigated in mice.The data showed that sodium ferulate could not only reduce the activities of serum alanine transaminase (ALT) and liver cytosol glutathione peroxidase (GSH-Px),but also increase both the activities of liver microsomal and cytosol glutathione S-transferases(GST) and the content of liver mitochondrial GSH in peracetamol(Par)-indueed hepatotoxicity mice.The da- ta also indicated that sodium ferulate could raise liver microsomal GST activity and protein con- tent in normal mice.These results suggested that sodium ferulate be able to enhance the detoxify- ing function of liver.