国产坎地沙坦酯对原发性高血压治疗6个月的有效及安全性观察

An 6-month open trial on Effects and safety of candesartan in patients with hypertension

目的观察国产坎地沙坦酯治疗高血压6个月中的有效性、安全性。方法选择45例18～65岁的中国轻、中度原发性高血压患者,经2周停服降压药后,口服坎地沙坦8mg,每天1次;4周后,若坐位舒张压(SiDBP)≥90mmHg时剂量加倍至24周。分别在用药后第2、4、6、8、12、16、20及24周末随访,观察其疗效和安全性。结果①坎地沙坦8～16mg/d,服药后第2、4、6、8、12、16、20及24周时,坐、立位舒张压、收缩压均明显下降(P均=0.0001)。②不良反应6.7%(头晕2例、头痛1例),且程度较轻。结论8～16mg/d坎地沙坦治疗原发性高血压6个月的疗效及耐受性较好。

Objective To evaluate the effect and safety of candesartan cilexitil made in China in patients with mild and moderate hypertension. Methods After 2-weeks wash-out, 45 patients with siting diastolic blood pressure （SiDBP） 95 - 115 mmHg received candesartan 8 mg QD for 4 weeks ;then ,if SiDBP ≥90 mm Hg, the dosage would be double till to 24 week treatment. All patients visited at 0, 2^nd ,4^th ,6^th, 8^th, 12^th, 16^th ,20^th, and 24^th wee respectively. Results ①The mean of SiDBP , SiSBP , standing DBP（StDBP） and StSBP all decreased significantly from baseline At 2^nd ,4^th ,6^th, 8^th, 12^th, 16^th ,20^th, and 24^th week of treatment with candesartan cilexitil 8-16mg once daily（ all P = 0. 0001 ）.② There were a few and mild advent reactions（6.7% ） during 6 months . Conclusion Administration of candesartan cilexitil orally 8- 16mg once daily appears to be a well-tolerated, safe, and effective antihvpertensive treatment.