药物微粉制备及防团聚技术

Technologies for preparation and anti-reuniting of ultra fine powder of pharmaceuticals

最佳的给药途径是呼吸道吸入,要求药粉粒径在0.5～7μm,满足此粒度要求的微粉制备方法有:物理粉碎法,包括机械超细粉碎与气流粉碎;物理化学合成法,包括喷雾干燥、原位微粉化及超临界流体技术.简要介绍了这些方法,并预测未来技术发展趋势为:微粉制备与表面改性一体化技术(原位技术)、物理粉碎法与物理化学合成法的组合技术和粒度自动检测技术.

The best path for using pharmaceuticals is the way of respiratory inbreathing. For this the pharmaceutical particle diameter must be in 0.5-7.0μm. The preparation methods for such powder include： physical methods, such as mechanical milling and fluid energy milling; and physical chemical methods, including spray-drying, micronization in situ, supercritical fluid technologies, etc. In this paper the methods given above are briefly introduced and the developing trends of them are forecasted as follows： integration of preparation with surface modification（ i. e., in-situ technology）, combination technology of physical milling with physical chemical synthesis and atito-detecting technology for granularity.