摘要
目的:探讨急性心肌梗死(AM I)介入治疗(PC I)后白介素-8(IL-8)、可溶性细胞间黏附分子-1(sICAM-1)变化与心肌灌注的关系。方法:AM I(ST段抬高)病人98例,接受急诊PC I治疗,于术前5 m in,术后6 h、12 h、24 h分别抽取动脉血标本,采用酶联免疫双抗体夹心法(EL ISA)检测sICAM-1及IL-8。PC I术后1m o做双核素心肌灌注显像(D ISA SPECT)检查,根据心肌灌注程度分为心肌灌注不良组、心肌灌注良好组。结果:IL-8在PC I术前5 m in两组均已呈现升高趋势(P=0.728);术后6 h心肌灌注不良组进一步升高达峰值(P=0.001);术后12 h(P=0.009)、24 h(P=0.023)心肌灌注不良组仍高于心肌灌注良好组。sICAM-1在PC I术前5 m in两组间无显著差异(P=0.099);术后6 h、12 h、24 h均持续高于心肌灌注良好组(P<0.05)。结论:AM I病人PC I术后心肌灌注不良组血浆IL-8,sICAM-1水平明显高于心肌灌注良好组,提示细胞因子IL-8,sICAM-1参与血运重建后心肌灌注障碍的发生、发展。
Objective： To investigate the effect of plasma levels of IL-8, slCAM-1 on myocardial reperfusion with patients of acute myocardial infarction after PCI. Methods ： Ninety-eight patients with acute myocardial infarction after PCI were enrolled in this study. All patients received DISA SPECT examination after PCI 1 month. All patients underwent evaluation of TMP, CTFC and computed sum STR, max STE immediately after PCI therapy. Enzyme-linked immunosorbent assay （ELISA） was used to measure the plasma level of IL-8, sICAM-1 before 5 min and after PCI 6h, 12h, 24h, respectively. Results： Plasma level of IL-8, sICAM- 1 for patients without myocardial perfusion assessed by DISA SPECT were persistently higher than those with myocardial perfusion after PCI 6h, 12h, 24h. Conclusion： Cytokine of IL-8, sICAM-1 may involve in the development of myocardial perfusion disorder.
出处
《内蒙古医学院学报》
2005年第3期185-188,共4页
Acta Academiae Medicinae Neimongol
基金
内蒙古自然科学基金项目(200508010923)
