普贝生用于足月引产的临床观察30例分析

Clinical Efficacy and Safety of Prostaglandin E_2 in Term Induced Labor

目的:探讨普贝生用于单胎足月引产的有效性及安全性。方法:采用病例对照研究的方法,对30例孕周超过37周、单胎无妊娠合并症的初产妇,以阴道放置普贝生为观察组,30例不用普贝生的病例为对照组。比较使用后的宫颈成熟及分娩情况。结果:观察组产妇给药后Bishop评分,23例提高≥2分,而对照组仅5例提高2分,两组比较,差别有极显著性(P<0.01)。观察组从给药到分娩的时间为(24±2)小时,对照组为(72±6)小时,两组比较,差别有极显著性(P<0.01)。结论:普贝生可安全、有效地用于足月引产。

Objective：To determine the efficacy and safety of Prostaglandin E2 in term induced labor in clinic. Methods： 30 primiparity pregnant women, gestational period over 37 weeks, were assigned in the test group in which the prostaglandin E2 was taken in the vagina; other 30 cases served asthe control group in which no prostaglandin E2 was used. Comparison of cervix change was observed. Results： 23 of 30 test women elevated the 2 Bishop marks but only 5 of 30 control women （P 〈 0.001 ）, and the time from taking the drug to labor continued for 24 hr, in the test group but 72 hrs in the controls （P 〈0.01 ）. Conclusions： Use of prostaglandin E2 in term - induced labor is efficacy and safety in the clinic.