摘要
19例心功能障碍患者的血浆、心肌血管紧张素Ⅱ(AngⅡ)、心钠素(ANF)含量高于正常对照组;血浆AngⅡ和ANF含量增高与心脏指数(CI)呈显著负相关(r=-0.5968,P<0.05;r=-0.8996,P<0.01),心肌AngⅡ含量变化与左室心肌重量(LVM)呈显著正相关(r=0.5723,P<0.05);提示心脏局部肾素-血管紧张素系统(RAS)活性增高和ANF变化参与心肌细胞增殖及心室重塑的意义较为突出。
Theplasmaandcardiactisuereninactivity(RA),angiotensinⅡ(AngⅡ)andatrialnatriureticfactor(ANF)werequantifiedbyspecificradioimmunoassayin19patientswithcardiacin-suficiencyduetochronicrheumaticheartvalvedisease.TheincreasedplasmaAngⅡandANFinpa-tientswithchronicrheumaticheartvalvediseasewereinasignificantlyinverserelationwiththecardicindex(P<0.01).RA,AngⅡandANFofventricularmyocardiumwerehigherinpatientsthaninnormal(P<0.01).ThemyocardiumAngⅡinpatientswithchronicrheumaticheartvalvediseasecorelatedpositivelywiththemassofleftventricle(P<0.05).Ourresultssuggestedthattheactivatedcardiaclocalrenin-angiotensinsystemcouldenhancethemyocardialinotropicroleandseemedtobemoresignificantinthehypertrophyofcelsandcardiacremodeling.TheincreasedANFinventricularmyocardiumplaysanimportantroleinthecardiacfunction.
出处
《中华心血管病杂志》
CSCD
北大核心
1996年第1期9-11,共3页
Chinese Journal of Cardiology
基金
国家自然科学基金
关键词
心功能试验
肾素
血管紧张素
心钠素
heartfunctiontestsrenin-angiotensinsystematrialnatriureticfactor