假性性早熟38例临床分析

Clinical Analysis of 38 Cases of Pseudoprecocious Puberty

目的研究假性性早熟(PPP)的病因、临床特征、诊治及预后。方法应用促性腺激素释放激素类似物兴奋试验检测促性腺激素(促卵泡激素、促黄体生成激素)、雌二醇、B超检查、骨龄评估等方法对38例PPP儿童进行诊断,并给予治疗及随访。结果LH峰值(0.49±0.48)IU/L,FSH峰值(0.54±0.78)IU/L,26例E2升高(36.11±15.07)ng/L,1例17羟孕酮> 266 nmol/L,B超均示子宫增大(3.98±1.18)mL。误服避孕药29例。McCune-Albright综合征5例,卵巢囊肿2例,卵巢颗粒细胞瘤、先天性肾上腺皮质功能增生症各1例。结论PPP病因多样,早期诊断、治疗十分重要。

Objective To study the eauses, clinical feature, diagnoses and prognosis of pseudoprecocious puberty. Methods Thirty - eight cases with pseudoprecocious puberty were diagnosed by the serum LH and FSH of GnRHa stimulation test, pelvic uhrasonography and bone age assessment; they were treated and followed up. Results Peaks of LH were（0.49 ± 0.48） IU/L, peaks of FSH were（0.54 ± 0.78） IU/L, the level of E2 in 26 cases increased （36.11 ± 15.70） ng/L, 17 - hydroxyprogesterone of 1 ease was beyond 266 nmol/L. All cases showed hysterauxesis （ 3.98 ± 1.18） mL. Cases of wrong contraceptive intake were 29,5 cases of McCune - Al- bright syndrome,2 cases of ovarian cyst, 1 case of ovarian granular cell tumor, 1 ease of congenital adrenal hyperplasia. Conclusions The causes of pseudoprecxocious puberty are multifactors, Early diagnosis, therapy, follow- up are very important for prognosis.