健康和乙型肝炎病毒携带儿童中输血传播病毒的感染状况

Comparison of Transfusion Transmitted Virus Infection between Normal Children and Hepatitis B Virus Carrying Children

目的探讨输血传播病毒(TTV)在新疆体检健康和HBV携带儿童中的感染情况,评价TTV的致病性。方法采用套式PCR方法,对230例体检儿童(HBsAg阴性儿童160例,HBV携带儿童70例)血清进行TTV-DNA检测。结果体检儿童230例中共检出40例TTV-DNA阳性,检出率为17.4%.其中HBV阴性健康儿童TTV-DNA阳性22例(13.7%),HBV携带儿童TTV-DNA阳性18例(25.7%),两组比较有显著差异(P<0.05)。结论新疆儿童中存在TTV感染,HBV携带儿童中TTV感染率较高。

Objective To study the prevalence of transfusion transmitted virus （TTV） in normal children mid hepatitis B virus （FIBV） carrying children. Methods Aalested polymerase chain rcaction（nPCR） assay was established using two - set of primers designed from the first open read frame of TTV genome. Serum from the children who received physical examination was tested by nPCR as,say for the presence of TTV - DNA. Results The total detectable rate of TTV - DNA in those 230 objects was 17.4 %, in which the positive rate of TTV - DNA was 13.7% in nomna[ children and was 25.7% in children carrying FIBV. There was significant difference in the positive rate of TTV - DNA between normal children and the children carrying FIBV. Conclusion There is TTV infection in normal children,and there is higher positive rate of TTV- DNA in children carrying FIBV in Xinjiang.