儿童免疫相关性疾病的常规免疫学指标研究

Study on Immunological Parameters in Immunology Related Diseases in Children

目的比较特发性血小板减少性紫癜(ITP)、过敏性紫癜(HSP)及皮肤黏膜淋巴结综合征(KD)的常规免疫学指标变化及静脉注射免疫球蛋白(IVIG)的应用。方法用流式细胞仪测T细胞亚群,免疫比浊法测免疫球蛋白(Ig)及补体。常规加IVIG治疗。结果ITP患儿CD3+CD4+T细胞降低并IgG升高;HSP患儿IgA升高伴CD3+T细胞增高。KD患儿CD3+ CD8+T细胞降低。IVIG可明显改善3种疾病临床症状,尤其有助KD患儿冠状动脉损害发生率减少。结论T细胞亚群、lg 应作为ITP、HSP及KD的常规检查项目。早期应用IVIG对改善预后及缩短病程有重要意义。

Objective To observe the changes of immunological paranleters and the effects of intravenous inanunoglobulin （IVIG） in children with idiopathic thrombocytopanic purpura （ITP）,mhonlein Henoch purpura（HSP） and mucocutaneous lymph node syndrome（kawasaki disease, KD）. Methods T cell subsets and serum immunoglobulins and complements were measured with the flow cytometry and enhanced trubidimetric inmmnoassay. Routine therapy combined with IVIG. Results CD3^＋CD4^＋ T cells were decreed in children with ITP accompanied by increased serum IgG ;Serum IgA and CD3^＋ T cells were increased in children with HSP; CD3^＋ CD8^＋T cells were decreased in children with KI）. Clinical features were nmrkedly improved after treatment with IVIG. It was noted that the incidence of damage to coronary artery decreased after the use of IVIG. Conclusions T cell subsets, seruni immunoglobulins should underl4o the clinical routine examinations in ITP, HSP and KD. Early administration of IVIG might be important to improve disease prognosis and shorten its courm of treatment in children with three kinds of immunology related diseases.