天然牛磺酸在小儿心脏畸形纠治术中对心肌缺血－再灌注损伤的预防

Naturaltaurineinpreventingmyocardialischemia┐reperfusioninjuryonoperatedcasesofcongenitalheartmalformation

观察在先天性心脏畸形手术纠治病例，服用天然牛磺酸后心肌内牛磺酸含量，历３０～７０分钟冠状动脉断流后心肌线粒体变化和血清门冬氨酸氨基转移酶（ＡＳＴ）的活力；探讨天然牛磺酸在预防心肌缺血－再灌注损伤中的临床意义。结果显示，服用天然牛磺酸后的心肌内牛磺酸显著高于对照组；心肌线粒体的自身对照未出现体积增大，膜密度降低的缺血后改变，术后也未有与再灌注损伤有关的ＡＳＴ升高。结果说明，口服天然牛磺酸能有效地提高机体组织的牛磺酸水平，有显著的预防心肌缺血再灌注损伤的效应。

Thisisanexplorationabouttheclinicalvalueofadministeringnaturaltaurineinpre-ventingmyocardialischemia-reperfusioninjury.Intheoperatedcasesofcardiacmalformation,after30-70minutesofmyocardialischemiacausedbyocclusionofcoronaryarteryduringopenheartsurgery,theconcentrationoftaurineinthemyocardium,thechangeofmyocardialmitochondriaandtheactivityofserumaspartateaminotransferaseweredetermined.Theresultsshowedthatthereweresignificantlyhigherconcentrationoftaurineinthemyocardiumofthosewhotooknaturaltau-rine(n=23)thanthoseofthecontrol(n=23);therewerenovolumeexpansionanddecreaseofmembranedensityinthemitochondriawithischemiaandnoriseofserumaspartateaminotransferaseactivity.Theevidenceshowsthatnaturaltaurinevalidlyraisestaurinelevelinthetissuesandcausesremarkablepreventiveefectonmyocardialischemia-reperfusioninjury.