男性肝硬化患者血清性激素与垂体激素水平变化及意义

Sex Hormone and Hypophyseal Hormone Alterations in Male Liver Cirrhosis Patients and Their Clinical Significance

目的探讨男性肝硬化患者性激素与垂体激素的变化及其临床意义。方法对92例男性肝硬化患者进行血清睾丸酮(T)、雌二醇(E2)、泌乳素(PRL)、黄体生成素(LH)、卵泡刺激素(FSH)检测,并与正常对照组比较。结果肝硬化组T、E2浓度明显低于正常对照组,FSH、LH、PRL浓度明显高于正常对照组,与正常对照组比较有显著性差异(P<0.01),各级肝硬化组之间及与正常对照组的比较均有显著性差异。结论T、E2降低和FSH、LH、PRL升高可作为估计男性肝硬化患者肝功能损害程度和估计预后的重要指标。

Objective To evaluate the sex hormone and hypophyseal hormone alterations in male liver cirrhosis patients and their clinical significance. Methods The serum testosterone （T）, estradiol （E2）, prolactin （PRL）, luteinizing hormone （LH）, follicle stimulating hormone （FSH） levels were measured and analyzed in 92 male patients with liver cirrhosis and 48 normal controls. Results The serum concentrations of T, E2 were decreased and the serum FSH, LH and PRL levels were increased in the patient group. A significant difference between the cirrhotic patients and the normal controls was found, and was different among the A, B and C groups. Conclusion The decreased serum T, E2 and increased FSH, LH and PRL levels might be useful as a group of parameters to estimate the severity of liver damage and prognosis in male cirrhosis patients.