甲孕酮伍用止吐药预防化疗引起的恶心呕吐

Medroxyprogesterone Acetate with Antiemetics: Efficacy in ControllingAnorexia, Nausea and Vomiting Induced by Chemotherapy

止吐药已基本能控制化疗呕吐，但化疗引起的食欲不振和恶心尚末引起充分注意。本文旨在观察甲孕酮与胃复安、地塞米松联合应用是否可进一步减轻这些化疗反应。结果表明，加用甲孕酮的病人，６３％末出现恶心，而对照组仅２９％（Ｐ＜０．０５）；对预防化疗引起的呕吐有一定增强效果，但无统计学意义；对食欲的保护最为明显，化疗期间及化疗后食欲不减或有所增加者占７３％，对照组仅１９％（Ｐ＜０．０５）。即使发生食欲者，其幅度和持续时间也明显低于对照组。作者认为，甲孕酮与止吐药合用可进一步减少化疗的消化道并发症，对提高病人的生活质量、保证抗肿瘤治疗顺利进行具有重要意义。

Anorexia,nausea and vomiting are common chemotherapy complications.Though the vomiting could be controlled with antiemitics generally,the anorexiaand nausea have not been dealed with successfully. This paper was developed toobsere the efficacy of Medroxyprogesterone Acetaote(MPA)in preventing thecomplications.The result showed that unchanged or improved appetite after chemotherapywas 73% in the MPA patients and 19% in the control group(P<0. 005). No nausea occurrence was 63% and 29% respectivelyly (P<0. 05). If anorexia was complained by the MPA patients.the strength andlength were less obviously than the control group. There did not have significant difference in controling the vomiting with MPA addition. Transient mild edema wasobserved in the MPA group.It is concluded that MPA with antiemetics can prevent better the anorexia andnausea induced by chemotherapy than antiemetics only.