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金属基质蛋白酶及其抑制物与子宫内膜癌 被引量：1

Matrix Metalloproteinases,Tissue Inhibitor of Metalloproteinases and Endometrial Carcinoma
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摘要 细胞外基质 (ECM)降解是肿瘤侵袭转移的重要信号和途径。金属基质蛋白酶 (MMPs)是溶解基质的一组重要酶类。金属基质蛋白酶组织抑制剂 (TIMPs)是MMPs的特异性抑制物 ,两者的表达 ,代谢平衡与子宫内膜癌的浸润转移 ,生理病理和临床预后有密切关系。MMPs-TIMPs调节失衡 ,ECM降解以及基底膜消失 ,均可促进子宫内膜癌的发生浸润转移。MMPs,TIMPs表达量的检测可作为早期诊断 ,监测妇科恶性肿瘤的理想标志物 ,并可针对其平衡采取相应的肿瘤治疗措施。
作者 侯敏敏 郄明蓉
机构地区 四川大学华西第二医院妇产科
出处 《华西医学》 CAS 2005年第1期182-183,共2页 West China Medical Journal
关键词 子宫内膜癌 金属基质蛋白酶 金属基质蛋白酶组织抑制剂
分类号 R737.33 [医药卫生—肿瘤]
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参考文献7

  • 1Bode W, Fernades-Catalan C, Tschesche H, et al. Insight into MMP-TIMP interactions[J]. Cell Mol Life Sci,2001,54(4):639.
  • 2Massova I, Kotra LP, Fridman R, et al. Matrix metalloproteinase structures evolution,and diversification[J]. FASEB J,2000,10(12):1075.
  • 3Chambers AF, Matrision LM. Changing views of the role of metrix matalloproteinase in metatasis[J].J Natl Cancer Inst,2000,89(8):1260.
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  • 5Lurlaoo M, Loverro G, Vacca A, et al. Angiogenesis extent and expression of MMP-2 and MMP-7 correlated with upgrading and myometrial invasion in endometrial carcinoma[J]. Eur J Clin Invest,2001,29(9):93-801.
  • 6Ueno H, Yamashita K, Azamano I,et al. Enhanced production and activation of MMP-7 in human endometrial carcinomas[J]. Int J Cancer,2001,84(5):470-477.
  • 7Fata JE, Ho AT, Leco KJ, et al. Cellular turnover and extracellular matrix remodeling in female reproductive tissues: function of MMPs and their inhibitors[J].Cell Mol Life Sci, 2000, 57(1):77-95.

同被引文献35

  • 1刘谟震,赵俊军,吕德成.基质金属蛋白酶与类风湿关节炎等疾病的关系[J].中国临床康复,2005,9(23):158-159. 被引量：6
  • 2谢建民,余步云,陆才生.VEGF在类风湿关节炎滑液中的表达及上调MMP-2活性的研究[J].中华风湿病学杂志,2006,10(8):495-497. 被引量：7
  • 3RATH T, RODERFELD M, GRAF J, et al. Matrix metalloprotei- nase inflammatory bowel disease from basic research to clinical sig- nify cance[J]. Z Gastroenterol, 2009, 47(8) : 758 -769.
  • 4KIM KS, LEEYA, CHOIHM, et al. Implication of MMP-9 and urokinase plasminogen activator (uPA) in the activation of pro - matrix metalloproteinase (MMP) - 13 [ J]. Rheumatol Int, 2012, 32 (10) : 3069 - 3075.
  • 5MOR A, ABRAMSON S B, PILLINGER M H, et al. The fibrolast - like synovial cell in rheumatoid arthritis: a key player in inflamma- tion and joint destruction [ J ]. Clin Inamunol, 2005, 115 (2) : 118 - 128.
  • 6NOSS E H, CHANG S K, WATFS G F, et al. Modulation of ma- trix metalloproteinase production by rheumatoid arthritis synovial fi- broblasts after cadherin 11 engagement [ J ]. Arthritis Rheum, 2011, 63(12) : 3768 -3778.
  • 7ZHU P, LU N, SHI Z. CD147 over expression on synoviocyte in rheumatoid arthritis enhances matrix metalloproteinas production andinvasiveness of synovioeytes[ J]. Arthritis Res Ther, 2006, 8 (2) : R44 - R48.
  • 8TOLBOOM T C, PIETERMAN E, VAN DER LAAN W H, et al. Invasive properties of fibroblast - like synoviocytes: correlation with growth characteristics and expression of MMP - 1/MMP -3 and MMP - 10 [ J ]. Ann Rheum Dis, 2002, 61 ( 11 ) : 975 - 980.
  • 9LEE Y A, CHOI H M, LEE S H, et al. Hypoxia differentially af- fects IL - 1β - stimulated MMP - 1 and MMP - 13 expression of fibroblast - like synoviocytes in an HIF - 1 ct - dependent manner [J]. Rhenmatology (Oxford), 2012, 51 (3): 443-450.
  • 10UCHIBORI M, NISHIDA Y, TABATA I. Expression of matrix metalloproteinases and tissue inhibitors of metalloproteinases in pigmented villonodular synovitis suggests their potential role for joint destruction[ J]. J Rheum Atol, 2004, 31 (1) : 110 -119.

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华西医学
2005年 第1期

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