奥曲肽与易蒙停治疗5-氟脲嘧啶诱导的腹泻的临床对比观察

Comparalve Study of Octreotide and Loperamide in the Treatmentof 5-Fluorouracial-induced Diarrhea

目的 :分别观察奥曲肽和易蒙停治疗 5 -氟脲嘧啶诱导的腹泻的疗效和腹泻完全的中位时间并行对比分析。方法 :30例 5 -氟脲嘧啶诱导的腹泻病人分为奥曲肽治疗组 (OCT组 ) 14例和易蒙停治疗组 (LOP组 ) 16 例 ,OCT组接受奥曲肽 10 0 μg皮下注射 8小时一次 ,LOP组接受易蒙停 4mg口服 1天 3次 ,观察腹泻完全缓解率和腹泻完全缓解的中位时间。结果 :OCT组的腹泻完全缓解率为 78 5 7% (11/ 14 ) ,LOP组为 4 3 75 % (7/ 16 ) ,二组比较有显著性差异 (P <0 0 5 ) ;DCT组腹泻完全缓解的中位时间为 3天 ,LOP组为 6 5天。结论 :奥曲肽用于治疗 5 -氟脲嘧啶诱导的腹泻 ,较易蒙停有更高的缓解率 ,能在更短的时间内缓解腹泻。

Objective： To observe the complete response rate of diarrhea and median time of response to oetreotide and loperamide in 5 - Fluorouracial- induced diarrhea. Method： 30 cases patients with 5 - Fluorouraeial- induced diarrhea are divided into octreotide group （OCT group 14） and loperamide group （LOP group 16） respectively. Result： The complete response rate of diarrhea is 78.57% （11/14） in OCT group and 43.75% （7/16） in LOP group. There was satatistically significant difference beaween these twe groups （ P 〈 0.05）, The midian time of complete response was 3 day,s in OCT group and 6.5 day,s in LOP group. Conclusion： Oetveotide was more effect than loperamide in 5- Fluorouraeial- induced diarrhea, and may improve diarrhea in shirt period.