针刺内关穴对机体不同功能状态下fMRI脑功能成像的影响

Effects of acupuncture at Neiguan (PC 6) on human brain functional imaging in different functional states

目的:观察机体在生理或病理状态下,针刺同一穴位时fMRI脑功能成像的变化,探讨内关穴的作用机制。方法:对老年健康人(正常组)和阿尔茨海默病患者(AD组)进行电针刺激内关穴,同时运用1.5T磁共振成像系统,采集两组被试者脑部的fMRI功能像数据,通过SPM99进行统计分析,获取正常组和AD组脑内不同区域的功能活动图像。结果:正常组两侧额叶及颞叶均被不同程度激活,AD组表现在额叶、颞叶和扣带回、小脑等部位不同程度的激活,其他脑区无明显激活。结论:针刺内关穴对正常组和AD组的脑功能活动激活区域表现不同,说明针刺内关穴对机体不同功能状态下fMRI脑功能成像影响不同。

Objective To study on effects of acupuncture at a same point at physiological or pathological state on brain functional imaging, Methods Electroacupuncture was given at Neiguan （PC 6） of the healthy senile persons （normal group） and the patients of Alzheimer＇s disease （AD group）, and they were scanned on a 1.5 T MRI scanner and the data of functional magnetic resonance imaging （fMRI） were analyzed by Statistical Parametric Mapping （SPM99）. The functional imaging of different brain regions were obtained from both the healthy group and the AD group. Results Both the frontal lobe and the temporal lobe were activated in varying degrees by electroacupuncture at Neiguan （PC 6） in the healthy group. However, the frontal lobe, the temporal lobe and the cingulate gyrus as well as the cerebellum were activated in varying degrees and other brain regions were not activated by electroacupuncture at Neiguan （PC 6） in the AD group. Conclusion Acupuncture at Neiguan （PC 6） can activate functions of different brain regions in the healthy group and the AD group, indicating that acupuncture at Nelguan （PC 6） has different effects on functional magnetic resonance imaging in different functional states.