血清可溶性P-选择素在评价类风湿关节炎病情及预后中的意义

Significance of Serum Soluble P-selectin in Evaluating Disease Activity and Prognosis of Rheumatoid Arthritis

目的探讨可溶性P-选择素(sP-选择素)对评价类风湿关节炎(rheumatoidarthritis,RA)病情及预后的临床意义。方法利用酶联免疫吸附分析(ELISA)方法检测血清sP-选择素水平。结果发现RA患者血清中sP-选择素的水平高于正常对照组(P≤0.05);RA患者血清中sP-选择素的水平与RA病情活动指标(晨僵、休息痛、关节压痛指数、关节肿胀指数、类风湿因子、C-反应蛋白、血沉及stoke指数)呈正相关,且与RA病情活动程度呈正相关;RA患者经6个月治疗后,其疗效与sP-选择素呈负相关(P≤0.05)。结论RA患者sP-选择素水平增高,提示病情严重,预后较差;sP-选择素与RA病情活动程度密切相关,可作为评价RA活动性、疗效及判断预后的指标。

Objective To assess the clinical significance of serum soluble P- selectin in evaluating disease activity and prognosis in rheumatoid arthritis （RA）. Methods ELISA technique tested the serum soluble P- selectin levels. Results It was found that in RA patients there was higher levels of soluble P- selectin than that in normal controls（P≤0.05）. The levels of serum soluble P - selectin were correlated positively with disease activity indexes （morning stiffness, rest pain, tender articular index, swollen articular index, RF, ORP, ESR and stoke index） and there was positive relation between soluble P - selectin and RA disease activity（ r = 0.513, P≤0.01 ）. After 6 months treatment, there showed negative correlation between curative effect and sP- selectin. Therapeutic effect of patients with high levels of sP- selectin was inferior to that of patients with lower ones. Conclusion RA patients with high levels of sP- selectin usually have severe disease activity and poor prognosis. The level of sP selectin has significant correlation with disease activity, which provides a convenient indicator to evaluate disease activity, drug efficacy and prognosis in RA patients.