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铜绿假单胞菌对碳青霉烯类抗生素的耐药性 被引量：21

Carbapenems resistance and mechanism of Pseudomonas aeruginsa
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摘要 铜绿假单胞菌因其固有与获得性耐药,使抗菌药物的选择成为困惑医师的一大难题。碳青霉烯类抗生素由于其独特的抗菌优势受到临床医师的青睐,但随着使用的日益广泛,耐碳青霉烯类的铜绿假单胞菌也日益增多。铜绿假单胞菌对碳青霉烯类抗生素主要存在以下几种耐药机理:①β-内酰胺酶的水解作用(碳青霉烯酶、Am pC酶和ESBL s);②外膜通透性下降(O prD 2突变或缺失);③主动外排机制;④改变抗菌药物作用的靶位。铜绿假单胞菌对抗生素的耐药往往不是由单一因素造成的,且不同碳青霉烯类抗生素之间耐药机制存在差异。
作者 刘永芳 吕晓菊
机构地区 四川大学华西临床医学院感染性疾病中心
出处 《中国抗生素杂志》 CAS CSCD 北大核心 2005年第11期699-704,共6页 Chinese Journal of Antibiotics
关键词 铜绿假单胞菌 碳青霉烯类抗生素 耐药
分类号 R378.991 [医药卫生—病原生物学]
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参考文献35

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二级参考文献8

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共引文献421

同被引文献165

引证文献21

二级引证文献126

中国抗生素杂志
2005年 第11期

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