甲状腺功能亢进症病人围手术期血清甲状腺激素水平变化的研究

Changes on The Level of Perioperative Serum Thyroid Hormone in Patients with Hyperthyreosis

目的:探讨围手术期碘剂对患者体内甲状腺素的影响。方法:60例患者均经内科门诊口服抗甲状腺药物治疗1个月以上,然后转外科。用放免法测定手术前后病人不同时间的T3、T4、TSH的变化。结果:本组全部病例病情均稳定控制,甲状腺缩小、变硬,如期手术,无危象及呼吸道并发症发生,治愈率100%。T3、T4、TSH服碘前和术晨比较无显著性差异,但术后24h、48h下降明显(P<0.01)。结论:碘剂的应用是甲亢术前准备用药中最安全可靠的方法,术后服碘已无实际意义。

Objective：To study the effect of iodides on thyroid hormone in perioperative hyperthyroidisis patients. Methods：60 patients with hypertbyreosis took oral antithyroid drug over 1 month before performing operation. The changes of T3 and T4 and TSH were measured with radioimmunological assay before and after operation. Results：All patients condition was ideally controlled with decreasing and sclerosed thyroid gland. There was no thyroid crisis and respiratory complications occured. The cure rate was 100 %. The levels of T3, T4 and TSH showed no differences before taking iodides and in the morning of date of surgery,but decreased significantly at 24 hours and 48 hours after operation. Conclusion： The application of iodides is safe and reliable before operation, but it is meaningless after operation.