可控微结构支架光固化快速成形间接构造方法

STEREOLITHOGRAPHY RAPID PROTOTYPING INDIRECT FABRICATION APPROACH OF SCAFFOLDS WITH CONTROLLED MICROSTRUCTURE

提出一种以计算机辅助设计(CAD)和光固化快速成形为基础,精确设计和控制支架内部微观结构,实现支架外形与内部可控微结构一体化制造的方法。根据实际CT数据,应用三维CAD软件重构骨骼外形;依据利于细胞生长和促进成骨的原则,设计不同结构的支架内部微管道,控制微管道的尺寸、形状、走向、分支以及相互连通性。利用光固化快速成形技术构造相应的树脂模具,在模具中填充生物材料,待其固化后,通过热分解去除树脂模具,形成具有可控微结构的支架。光学显微镜下观察支架内部微管道结构,其结果与设计相符合。与传统支架构造方法相比,该方法在对支架外形重构和内部微结构制造的控制方面得到了改善。

An approach based on CAD and stereolithography rapid prototyping is proposed, which provides precise design and control of internal microstructure for scaffolds, achieves the integrated fabricated of external shape and internal microstructure of scaffolds. According to CT data, external shape of skeleton is reconstructed using CAD software. On the principle of facilitating cell growth and osteogensis, the internal microstructure including pore geometry, size, orientation, irtterconnectivity and branching is designed. The resin molds of scaf- folds are fabricated by stereolithography and the biomaterials are filled into the molds.Aider biomaterials in situ hardening, the molds are removed by pyrolysis The scaffolds with controlled microstucture are achieved. According to the observation under light microscope, the results indicate that the external shape and internal microstructure of scaffolds are in cornforo mity with the design. Compared with traditional scaffold fabrications; this method provides enhanced control over scaffold shape and internal microstruture.