鼻渊滴丸提取工艺的研究

Study on the Extraction Process of Biyuan Dropping Pills

目的对鼻渊滴丸提取工艺进行探讨。方法水提取工艺以浸膏得率和盐酸小檗碱含量为考察指标,蒸馏提取工艺以挥发油得率为考察指标,分别采用正交设计法对其最佳提取工艺条件进行优选。结果加15倍水,浸泡1h,煎煮3次,每次1h为水提最佳工艺条件;挥发油提取最佳工艺条件为:药材粗粉,加9倍量水浸泡1h,蒸馏提取4h。结论试验结果为确定鼻渊滴丸的提取工艺提供了试验依据。

Objective To optimize the conditions for the extraction process of Biyuan dropping pills. Methods With the obtaining rate of extract and the content of total berberine presented in the extract as the indexes for the water extraction process, and with the increase in the volatile oil as the indexes for the extraction of the volatile oil, orthogonal design was used to optimize the conditions for the extraction process respectively. Results The optimal conditions for the water extraction of Biyuan dropping pills was as follows： maceration 1 hour with 15 times water,decocting 3 times, 1 hour for each time. The optimal process of the volatile oil for Biyuan dropping Pills was to crush the herbal material into coarse powder, to macerate 1 hour with 9 times water and to distill for 4 hours. Conclusion This experimental results may provide the basis for the ascertainment of extraction process of Biyuan dropping pills at the manufacturing scale.