脑热清口服液解热抗炎作用的实验研究

Study on Antipyretic and Anti-inflammatory Effects of Naoreqing Oral Liquid

目的:观察脑热清口服液的解热和抗炎作用。方法:分别利用细菌内毒素和2,4-二硝基苯酚制备家兔感染性和非感染性发热模型,观察脑热清口服液的解热作用;采用二甲苯、H+等致炎因子引起的小鼠急性渗出性炎症,研究其抗炎的作用。结果:脑热清口服液能显著降低细菌内毒素引起的家兔感染性发热模型和2,4-二硝基苯酚致家兔非感染性发热模型动物的体温;对二甲苯、H+等致炎因子引起的小鼠急性渗出性炎症,有明显的抑制作用。结论:脑热清口服液对急性炎症反应有明显的抑制作用;对感染和非感染因素引起的发热反应均有明显的解热作用。

Objective：To study antipyretic and anti-inflammatory effects of Naoreqing oral liquid. Method：The models of infected and noninfected fever induced by bacterium endotoxin and 2, 4-binitro-phenol, were used to observe the antipyretic effects of Naoreqing oral liquid. Models of acute inflammatory reactions of xylene-induced mouse ear edema and H^＋ -induced mouse capillary permeability enhancement were performed to study the anti-inflammatory effects. Results： Naoreqing oral liquid indicated inhibition in the risting scope of temperature of the febrile rabbits. Naoreqing oral liquid significantly suppressed xylene-induced mouse ear edema and H^＋ -induced mouse capillary permeability enhancement. Conclusion： Naoreqing oral liquid manifested obvious anti-inflammatory effects on acute inflammatory reactions. The febrile reactions induced by infective and noninfective factors were significantly relieved by Naoreqing oral liquid.