氯诺昔康复合丙泊酚用于人工流产术的临床观察

The clinical investigation of propofol with lorixicam for induced abortion anesthesia

目的观察氯诺昔康复合丙泊酚用于无痛人工流产术的有效性和安全性。方法选择自愿行无痛人流术的病人80例,年龄18岁～30岁,无阴道分娩史,ASA:Ⅰ级,随机分两组,丙泊酚组(简称P组)和丙泊酚复合氯诺昔康组(简称PL组),每组40例,P组单纯用丙泊酚静脉注射,PL组在静注丙泊酚之前5～8分钟先静注氯诺昔康8mg,观察两组用药后BP,HR,RR,SpO2,丙泊酚用量,术中肢体活动情况,清醒时间,术后宫缩痛及其他不良反应。结果丙泊酚用量PL组少于P组,但无显著性差异,呼吸抑制发生率P组75%、PL组40%(P<0.05),术后宫缩痛发生率PL组5%明显少于P组30%(P<0.05),两组术中BP、HR、SpO2比较差异无显著性。结论氯诺昔康复合丙泊酚静脉麻醉行无痛人工流产术可以很好抑制术后宫缩痛,减少丙泊酚用量和呼吸抑制的发生且不增加不良反应。

Objective To investigate the efficacy and safety of propofol with lorixicam for induced abortion anesthesia. Methods The 80 cases of ASA status grade one early pregnant women without trans-vaginal delivery whose age ranged from 18 to 25 years were devided into two groups： group P and group PL （n=40）. The anesthesia was induced by intravenous administration of propofol in both two groups and the lorixicam was injected intravenously 5-8 minutes before propofol in PL group. The BP, HR, RR and SpO2 during anesthesia were monitored and recorded. The propofol dosage, the movement of patients limbs, the recover time, post-operative pain from uterine contraction and other side effects were also investigated. Results The propofol dosage in PL group is less than that in group P but without significant difference; The incidence of respiratory distress in group P is 75% while 40% in group P （P〈0.05）, The incidence of postoperative pain from uterine constraction in group PL 5% is lower than that in group P30%（P〈0.05）; the value of BP, HR, SpO2 in the two groups are with no significant difference. Conclusions The propofol intravenous anesthesia with lorixicam for induced abortion can inhibite the postoperative pain from uterine contraction, reduce the propofol dosade and the incidence of respiratory distress, without the increase of the side-effects.