参附注射液对全麻气管插管应激反应的影响

The Effects of Shenfu Injection On Lrritated Reaction During Anesthesia Induction and In Endotracheal Intubation

目的探讨参附注射液对于气管插管应激时引起的血流动力学及内分泌变化的影响。方法选取择期行全麻手术的病人30例,ASA分级Ⅰ—Ⅱ级,且排除高血压、肾脏及内分泌疾病,随机分为S组参附组和C组对照组,于诱导前,插管后3min和插管后10min抽取血标本监测血管紧张素Ⅱ(AⅡ),血浆醛固酮(ALD)和血清皮质醇(Cs)的浓度,监测HR,SBP和DBP的变化。结果S组在插管前后,HR,SBP和DBP比较稳定,P>0.05,AⅡ,ALD和Cs浓度变化无统计学差异。C组在诱导后,SBP和DBP明显下降P<0.05,插管后上升,AⅡ,ALD和Cs明显升高,有统计学意义P<0.05。结论参附注射液对于减轻气管插管时的应激反应有一定作用。

Objective To investigate the effects of shenfu injection on hemodynamics and irritated hormone during anesthesia induction and in endotracheal intubation. Methods 30 adult ASA Ⅰ-Ⅱ grade scheduled for surgery under general anesthesia were randomly divided into two groups including Shenfu （S） group and control （C） group. Inspect the concentration of Anglotensin Ⅱ （AⅡ ）, Aldosterone （ALD） and Cortisol （Cs） before anesthesia induction and 3 rain, 10 min after endotracheal intubation by blood sampling; supervise the variation of HR, SBP and DBP accordingly. Results In S group, before and after intubation, the level of HR, SBP and CBP has no prominence difference P〉0.05, the variation of AⅡ, ALD and Cs has no statistics difference, P〉 0.05. In C group, the level of SBP and DBP were significantly decreased after anesthesia induction and increased after intubation, P〈0.05. The concentration of AⅡ, ALD and Cs were distinctly increased, P〈0.05. Conclusions Shenf⒎ injection can ease the irritated reacton caused to the endotracheal intubation.