摘要
脊椎动物M sx基因为非连锁,包含果蝇肌节同源盒基因相关的一系列基因。在脊椎动物胚胎发育过程中,这些基因在组织间相互作用的多发位点表达。基因敲除鼠和人类的畸形表现型的研究显示,M sx基因介导的诱导组织间的相互作用,对正常颅颌面、肢体和外胚层器官的形态发生至关重要。该文就M sx基因在胚胎发育过程中的作用,以及该基因突变所致的颅颌面发育异常等方面的研究进展,进行综述。
Vertebrate Msx genes are unlinked, homeobox-containing genes that bear homology to the drosophila muscle segment homeobox genes. These genes are expressed at multiple sites of tissue-tissue interactions during vertebrate embryonic development. Inductive interactions mediated by the Msx genes are essential for normal craniofacial, limb and ectodermal organ morphogenesis as manifested by the phenotypic abnormalities shown in knockout mice and in humans. This review summarizes studies on the functional analysis of Msx genes that bear relevance to craniofacial development in humans and mice, and craniofacial disorders caused by mutations in Msxs.
出处
《上海第二医科大学学报》
CSCD
北大核心
2005年第10期1079-1083,共5页
Acta Universitatis Medicinalis Secondae Shanghai
