心肌声学造影评价慢性心肌缺血血流灌注的实验研究

An experimental study on assessment of myocardium perfusion in chronic ischemic myocardium with myocardial contract echocardiography

目的:探讨经静脉心肌声学造影(MCE)对慢性心肌缺血心肌血流灌注的诊断价值。方法:建立慢性心肌缺血猪模型,经外周静脉持续滴注微泡造影剂,分别于造模前、造模4周后测算A·β、标化A·β,比较造模前后心肌灌注图像及A·β、标化A·β。结果:造模前声学微泡在心肌组织中均匀分布,色泽明亮,A·β、标化A·β分别为49.82±14.07、1.01±0.21;Ameroid环套扎LCX后4周,局部心肌基本无灌注,回声低暗,A·β、标化A·β分别为4.08±3.56、0.13±0.07,明显低于造模前。结论:心肌声学造影可用于量化评估慢性心肌缺血时的心肌血流灌注状态。

Objective： To assess the diagnostic value of myocardial contrast echocardiography （MCE） in evaluation of myocardium perfusion of chronic ischemic myocardium. Methods： Chronic ischemic myocardium model was made in pigs. Microbubbles were administered as a constant venous infusion.A·β and normalized A·β were detected and compared before and after model-making respectively. Results： Before model-making microbubbles were distributed equably. A·β and normalized A·β were 49.82±14,07, 1.01±0.21 respectively; after that the ischemic myocardium was poorly perfused and A·β and normalized A·β were 4.08 ± 3.56,0.13± 0.07 respectively. Conclusion： Myocardial contrast echocardiography can evaluate myocardial perfusion of chronic ischemic mvocardial quantitativelv.