^(13)C-辛酸呼气试验与超声法诊断糖尿病性胃排空障碍的比较研究

Comparative study of ^(13)C octanoic acid breath test and gastric emptying ultrasonography for gastric emptying of meal in diabetic patients

目的:比较13C-辛酸呼气试验(OBT)与胃排空功能超声检测(GEU)在糖尿病患者胃排空功能检测中的一致性。方法:2型糖尿病患者71例,对照组30例,分别行OBT与GEU检测,评价胃排空功能,并分别比较两种检测手段所得参数的相关性。结果:OBT显示糖尿病组胃半排空时间(GET1/2)、延迟相时间(tlag)均明显延长,120min胃残留率(Ret120min)增加。GEU亦显示不同时点糖尿病组胃排空率延迟。两种方法在不同时间点胃排空率具有高度相关性,对照组:60minr=0.501P=0.005,120minr=0.526P=0.002;糖尿病组:60minr=0.604P<0.001,120minr=0.651P<0.001。结论:应用OBT方法检测糖尿病胃动力障碍与GEU所得结果一致性较好,OBT不失为一种相对理想和临床实用的检测方法。

Objective： The ^13C octanoic acid breath test （OBT） has been proposed as a reliable noninvasive test to measure gastric emptying. OBT has been compared with scintigraphy; however, there are no data comparing it with gastric emptying ultrasonography （GEU）.The aim of this study was to correlate gastric emptying of a solid meal, with OBT and GEU evaluated in diabetic and healthy group. Methods： A total of 71 patients with diabetes and 30 normal subjects ingested a standard test meal with 100 mg of ^13C octanoic acid. Breath samples for ^13CO2 analysis were collected. GEU was also performed. Lag time （tlag） and half gastric emptying time GET1/2 were calculated for OBT. Data were analyzed by the Student＇s t test for paired data, correlation coefficient, and regression line. Results： The results show a statistically significant longer tlag and GET1/2 for OBT in diabetes. A significant correlation was computed between OBT and GEU. Conclusion： Results show that both techniques give data in good correlation. Because OBT is less operator-dependent, it may be more useful in clinic.