血清尿酸与多发性硬化关系的研究

Study on the relationship between serum uric acid and multiple sclerosis

目的探讨多发性硬化(MS)患者血清尿酸水平的改变与临床的关系。方法检测88例MS患者(MS组)血清尿酸水平,分析其与临床分期、病程、病情的关系;并与其他神经系统炎症性疾病患者(O IND组)和健康体检人员(正常对照组)比较。结果MS组血清尿酸水平明显低于O IND组及正常对照组(均P<0.05)。处于MS急性复发期患者的血清尿酸水平低于缓解期患者(P<0.05)。血清尿酸水平与MS的临床分期独立相关(P<0.05),与病程和扩展后的功能障碍状况量表评分不相关(均P>0.05)。结论血清尿酸水平的变化可作为MS诊断及判断MS患者不同临床分期的辅助指标。

Objective To investigate the relationship between serum uric acid level in multiple sclerosis （MS） and the clinical activity of disease. Methods The serum levels of uric acid in 88 MS patients （48 females and 40 males） were measured and compared with the patients of other imflammatory neurological disease （OIND） and healthy donors. The relationships between serum uric acid level and clinical stage, course of disease and patient＇s condition were analyzed. Results MS patients had significantly lower serum uric acid levels in comparison with OIND patients and healthy donors （all P〈 0. 05 ）. MS patients had lower serum uric acid levels at relapse stage （P 〈 0. 05 ）. Serum uric acid level was independently correlated with clinical stage （P 〈 0. 05 ）, and was not related with course of disease and the score of EDSS （ all P 〉 0. 05 ）, Conclusion Serum uric acid level may be served as a auxiliary marker in diagnosing MS and judging its stage.