急性脑梗死患者血小板表达血小板内皮细胞黏附分子-1、P选择素的改变及其意义

Changes of CD31 and CD62p expressions in platelets of patients with acute cerebral infarction and its signification

目的观察急性脑梗死(AC I)患者血小板表达血小板内皮细胞黏附分子-1(CD31)、P选择素(CD62p)的改变及其意义。方法采用全血流式细胞术测定53例AC I患者发病48 h内血小板CD31、CD62p的表达水平,并与有脑梗死易患因素组及健康对照组比较。结果AC I组血小板表达CD31、CD62p[(90.91±15.39)%,(7.00±2.96)%]明显高于易患因素组和健康对照组(均P<0.001);AC I组中合并高血压或糖尿病患者血小板CD62p表达高于无高血压和糖尿病的患者(均P<0.01);血小板CD31、CD62p的表达与脑梗死体积正相关(r=0.39,P<0.05;r=0.63,P<0.01)。结论AC I发病后血小板表达CD31、CD62p显著增高,其表达程度与脑梗死体积以及是否合并高血压或糖尿病有关。

Objective To observe the changes of CD31 and CD62p expressions in platelets of patients with acute cerebral infarction （ ACI ） and its significance. Methods The expression levels of CD31 and CD62p of 53 patients with ACl were measured with whole blood flow cytometry within 48h after onset, and were compared with those of 38 patients with vascular risk factors （hypertension, diabetes, current smoking and hyperlipidemia） of cerebral infarction and 30 normal controls. Results The expression levels of CD31 and CD62p in patients with ACI [ （90. 91± 15.39）%, （7.00±2. 96）% respectively] were higher than those of patients with risk factors and normal controls （all P 〈0. 001 ）. In the group of ACl, CD62p levels in patients with hypertension or diabetes were higher than those of patients without hypertension or diabetes （all P〈 0. 01 ）. The expressions of CD31 and CD62p were correlated with the volume of cerebral infarction （ r = 0. 39, P 〈 0. 05 ; r = 0. 63, P 〈 0, 01 ）. Conclusion Expressions of CD31 and CD62p in platelets increase in patients with ACI, and they are correlated with the volume of cerebral infarction and whether the patient has hypertension or diabetes.