食管癌术后局部复发转移的放射治疗疗效分析

Radiotherapy for Loco-recurrent Esophageal Carcinoma after Surgery

目的探讨食管癌术后局部复发转移的放射治疗疗效。方法对52例纵隔和/或锁骨上复发及转移病灶进行放射治疗,常规分割,DT4800cGy^7000cGy。22例放疗后予PF方案(顺铂+5-Fu)或NP方案(长春瑞滨+顺铂)化疗。结果全组总的中位生存期为12个月,1、2、3年生存率分别是48.1%、25.4%和14.0%。术后分期、放疗剂量、放疗后化疗及近期疗效与预后相关。结论放射治疗是食管癌术后局部复发和淋巴结转移的有效治疗方法,放疗结合化疗可能对患者有益。

Objective To study the effect of radiotherapy for locoregionally recurrent esophageal cancer after surgery. Methods From Apri 1997 to October 2003,52 cases of locoregional recurrence were received radiotherapy. In all cases, radiation was administered 2 Gy per fraction and 5 fractions per week, with the total dose of 4800 cGy-7000 cGy. Twenty-two patients were received PF（DDP＋ 5-Fu） or NP（NVB＋ DDP） chemotherapy after radiotherapy. Results The overall median survival time was 12 months and 1, 2, 3 year survival rates were 48. 1% ,25. 4% and 14. 0%, respectively. Post-surgical stage,dose of radiation, combined radiochemotherapy and response rates were closely related to prognosis. Conclusion To patients with locoregional recurrence after surgery of esophageal carcinoma, radiotherapy is an effective method and combined therapy may prolong survival.