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小鼠卵丘透明质酸结合蛋白的分布 被引量：1

Distribution of hyaluronan binding proteins in cumulus oophorus of mice
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摘要 目的:观察小鼠卵丘细胞外基质透明质酸结合蛋白(HABPs)的分布,探讨HABPs对小鼠卵丘的结构和功能的影响。方法:应用免疫荧光双重染色检测HABPs在野生型和bikunin基因敲除小鼠卵丘细胞外基质中的表达。结果:HABPs在两型小鼠卵丘细胞外基质呈阳性表达,HABPs的缺失损害小鼠卵丘细胞外基质完整。结论:HABPs对卵丘细胞外基质的完整是必需的。 Objective： To study the distribution of hyaluronan binding proteins （HABPs） in the cumulus extacellular matrix of mice and investigate the effect of HABPs on the the structure and function of the cumulus oophorus. Methods.. Immunofluoresence staining was used to detect the distribution of HABPs in the cumulus matrix of wild-type and bikunin null mice. Results： HABPs-positive staining was found in the cumulus extracellular matrix of mice. The defficiency of the HABP impaired the integrity of cumulus extracellular matrix. Conclusion： HABPs is required for the integrity of intercellular matrices.
作者 吴吉文 王玮
机构地区 福建医科大学人体解剖学与组织胚胎学系
出处 《解剖学杂志》 CAS CSCD 北大核心 2005年第5期507-509,共3页 Chinese Journal of Anatomy
关键词 透明质酸结合蛋白 细胞外基质 卵丘 小鼠 hyaluronan binding proteins extracellular matrix cumulus oophorus mice
分类号 R-332 [医药卫生]
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参考文献7

  • 1Zhuo L, Yoneda M, Kimata K, et al. Defect in SHAP-hyaluronan complex causes severe female infertility. A study by inactivation of the bikunin gene in mice. J Biol Chem, 2001,276(2):7693-7696.
  • 2Fulop C, Szanto S, Mikecz K, et al. Impaired cumulus mucification and femal sterility in tumor necrosis factor-induced protein-6 deficient mice. Development, 2003,130(1):2253-2261.
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同被引文献8

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引证文献1

解剖学杂志
2005年 第5期

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