D-环丝氨酸对大鼠空间工作记忆的影响

The effects of D-cycloserine on spatial working memory in rats

目的:探讨D环丝氨酸对空间工作记忆损伤大鼠的治疗作用。方法:随机将32只大鼠分为4组:对照组、阿托品损伤组、生理盐水治疗组和D环丝氨酸治疗组,分别给予相应的药物处理后,训练动物学习水迷宫中延缓的位置非匹配作业,以大鼠选择游泳时的选择正确率及逃避潜伏期为评判标准。结果:阿托品损伤组大鼠的选择正确率显著降低(P<0.01),而逃避潜伏期无改变(P>0.05);D环丝氨酸治疗组大鼠在作业的最初3天,选择正确率明显提高(P<0.01),但自第4天起效果不明显(P>0.05);整个过程中逃避潜伏期无改变(P>0.05)。结论:D环丝氨酸对空间工作记忆损伤大鼠有短期治疗作用,长期用药后效果不明显。

Objective： To investigate the effect of D-cycloserine on spatial working memory in atropine injured rats. Methods： Rats were randomly divided into four groups： control group, atropine injured group, D-cycloserine and saline treated groups. All animals were treated with drugs respectively and trained with the delayed nonmatching-to-position task （DNMPT） in the water maze. The index of spatial working memory was determined by the choice accuracy and latency in choice swim. Results： Atropine decreased the choice accuracy significantly （P〈0.01） but did not change the latency of choice swim （P〉0.05）. D-cycloserine and atropine combined using enhanced the choice accuracy much more significantly than atropine alone did in the first three days of training （P〈0.01）, but this was not effect from the fourth day （P〉0.05）; this did not change the latency of choice swim during the training （P〉0.05）. Conclusion： D-cycloserine can facilitate the spatial working memory in the rats with memory impaired by atropine for short duration .