整合素与肿瘤转移

Integrin and tumor metastasis

整合素是细胞表面重要的粘附分子,它在机体内具有重要的生物学作用。本文从肿瘤细胞侵袭转移的过程出发,较全面地阐述了整合素与肿瘤转移的密切关系,为深入探讨整合素在肿瘤发生、发展中的作用,开发肿瘤治疗新思路提供了理论依据。

Integrin is an important cellular adhesion molecule, which mediates many biologic actions such as cell-cell adhesion or cell-extracellular matrix adhesion. The relationship between integrin and tumor metastasis, as well as the important role of integrin during tumor progress, is reviewed in this article, which gives us the theoretical base for new pathways of cancer treatment.