生殖系统念珠菌感染的菌型及对6种抗真菌药物的体外药敏分析

Detection of bacterial types and antibiotic susceptivity for candida from STD patients

目的检测性传播疾病病人念珠菌菌型及药物敏感性。方法采用法国梅里埃公司的ATB ID 32 C酵母菌鉴定反应板鉴定菌种和Rosco纸片扩散法进行念珠菌的体外药敏检测,比较不同菌型念珠菌的药敏趋势。结果临床155例生殖系统念珠菌感染者中白念珠菌110例(70.97%)、近平滑念珠菌22例(14.19%)、光滑念珠菌12例(7.74%)、热带念珠菌6例(3.87%)、其它念珠菌5例(3.23%),其药敏结果总体趋势为制霉菌素(100%)、伊曲康唑(89.03%)、氟康唑(95.48%)和酮康唑(96.13%)较为敏感,而益康唑(58.70%)和咪康唑(56.13%)的中介度和耐药性较高。结论唑类抗真菌药存在交叉耐药,不同菌型念珠菌药敏谱存在差异。

Objective To determine the bacterial types and antibiotic susceptibility of candida in sexually transmitted disease patients. Methods ATB ID 32 C bioMerieux France and Roseo Disk diffusion method was be used to do typing and drug sensitivity test of candida. Comparing the susceptibility for all kinds types of candida. Results 155 strains genital candida were isolated. Including 110 strains（70.97%） of candida albicans, 22 strains（ 14.19% ） of candida parapsilesis, 12 strains（7.74% ） of candida glabrata, 6 strnins（3.87% ） of candida tropicalis and 5 strains of the other candida. The higher susceptibilities to genital candida were nystatin （NYS） 100%, itraconazole（IT） 89.03%, fluconazole（FL） 95.48%, ketoconazole（KET） 96.13%, the higher resistances to genital candida were enconazole（ECO） 58.70% and miconazole（MIC） 56.13%. Condusion Resistant candida strains will, however, probably exsit in imidazole yeast-antifungal combination; there are differences of antibiotic sensitivity spectrum between all kinds types of candida.